Phosphorylation of irf3 antibody

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August undefined, 2024

WebMar 23, 2001 · Although the broad-spectrum kinase inhibitor staurosporine potently blocked IRF3 and -7 phosphorylation, inhibitors for protein kinase C, protein kinase A, MEK, SAPK, …

Anti-IRF3 antibody [IRF35I218] (ab50772) Abcam

WebSep 1, 2024 · Although phosphorylation of Ser82 phenocopies that of Ser339 and Ser97 in IFN-β activation, it controls the promoter binding ability of IRF3, an activation step … WebJan 29, 2015 · Phosphorylated MAVS and STING then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recruit IRF3 for its phosphorylation and activation by TBK1. We... billy jack haynes dead

Anti-IRF3 antibody (ab25950) Abcam

WebWestern blot analysis of Phospho-IRF3 pSer385 using Phospho-IRF3 pSer385 polyclonal antibody (Product # PA5-36775) at a dilution of 1:500. Lane 1: Hela cell lysate treated with PMA (100nM, 15min), Lane 2: … Web该IRF3 Polyclonal Antibody. This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha … WebThe induction of phosphorylation of STING on S366 of IRF3 on S396 was inhibited in T404E compared to WT or ... T404A, or T404E STAT2 were treated with cisplatin for 24 h. The … billy jack hebrew

DYRK2 Negatively Regulates Type I Interferon Induction by ... - PLOS

Anti-IRF3 (phospho S396) antibody (ab138449) Abcam

WebOverview Product name Anti-IRF3 (phospho S396) antibody See all IRF3 primary antibodies Description Rabbit polyclonal to IRF3 (phospho S396) Host species Rabbit Tested … WebD, IRF3 phosphorylation is inhibited by E3L. 293T cells were transfected with 10 μg of an IRF3 expression vector and 10 μg of E3L (lanes 3 and4) or K3L (lanes 5 and 6), infected … billy jack haynes youtubeWebApr 11, 2024 · In the TLR4-TRIF-IRF3-type I IFN signaling cascade, phosphorylation of the TBK1 kinase is a key step 2. Phosphorylated-TBK1 (pTBK1) subsequently phosphorylates IRF3, which then translocates... billy jack haynes today

"WebDeficiency of STING prevented IRF3 phosphorylation by ethanol or ER stress, and absence of IRF3 prevented hepatocyte apoptosis. The pathogenic role of IRF3 in ALD was independent of inflammation or Type-I interferons. Thus, STING and IRF3 are key determinants of ALD, linking ER stress signaling with the mitochondrial pathway of … " - Phosphorylation of irf3 antibody

Phosphorylation of irf3 antibody

Phospho-IRF3 (Ser396) Polyclonal Antibody - Thermo …

WebJan 24, 2016 · The IRF3 transcription factor is critical for the first line of defense against pathogens mainly through interferon β and antiviral gene expression. A detailed analysis … WebAug 16, 2024 · Phosphorylated IRF3 dissociates from the STING complex and translocates to the nucleus to induce transcription of innate immune effector genes, such as type I IFNs and proinflammatory cytokines...

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WebMar 1, 2024 · The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. WebAnti-IRF3 antibody [IRF35I218] (ab50772) Datasheet Reviews ( 3) Q&A (4) References (9) Key features and details Mouse monoclonal [IRF35I218] to IRF3 Suitable for: ICC/IF, WB, Flow Cyt Reacts with: Human Isotype: IgG1 You may also be interested in Primary Alexa Fluor® 488 Anti-PSMA antibody [GCP05] (ab187570)

WebJan 20, 2009 · In this study, we show that another kinase, c-Jun-NH2-terminal kinase (JNK), phosphorylates IRF3 on its N-terminal serine 173 residue, and TAK1 can stimulate IRF3 … WebJan 4, 2006 · The protein kinase TBK1 is a key regulator inducing phosphorylation of IRF3. The regulatory mechanisms during IRF3 activation remain poorly characterized. In the present study, we have identified by yeast two-hybrid approach a specific interaction between IRF3 and chaperone heat-shock protein of 90 kDa (Hsp90).

WebFigure Legend Snippet: Suppressed DOX-induced phosphorylation of IRF3, TBK1 and p65 was observed by immunoblot analysis following STING knockdown in HL-1 cells following DOX treatment (1 μm for 24 h). Quantitative data represent the relative ratio to total IRF3, TBK1 or p65 ( n = 6) Techniques Used: Western Blot WebMar 8, 2024 · The dimerization and phosphorylation of IRF3 as well as the phosphorylation of TBK1 are hallmarks of the cytosolic DNA-triggered signaling. These processes were apparently inhibited in Rnf185 knockdown L929 cells, when stimulating cells with HT-DNA (Figs 2A and S4A ).

WebOct 22, 2024 · IRF3 is a transcription factor that participated in type I IFN production, and its function is realized by transposition from the cytoplasm to the nucleus (Vandevenne et al., …

WebTBK1-dependent phosphorylation of IRF3 leads to its nuclear translocation and subsequent activation of transcriptional programs that ultimately lead to the production of inflammatory cytokines, ... Staining with a dsDNA-specific antibody showed that such treatment is sufficient to induce cytosolic accumulation of dsDNA (Fig 1J, ... billy jack holbrook fort payne alabamaWebSep 25, 2015 · Viral infection activates the transcription factors NF-κB and IRF3, which contribute to the induction of type I interferons (IFNs) and cellular antiviral responses. Protein kinases play a critical role in various signaling pathways by … billy jack haynes childhoodWebPolyclonal Antibody Services; Monoclonal Antibody Services; Anti-idiotype Antibody Services New! Antibody Production Services; Specialized Antibody Services ... Hantavirus GnT Elements Mediate TRAF3 Binding and Inhibit RIG-I/TBK1 directed IFNβ Transcription by Blocking IRF3 Phosphorylation. J Virol.. 2014-01; VS Matthys, V Cimica, N Dalrymple ... cymbalta reactionsWebProtein Mutation Frequency in Cancer. The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and … billy jack haynes foundWebPhospho-IRF3 (Ser396) Antibody (720012) in ICC/IF. Immunofluorescence was performed on fixed and permeabilized HeLa cells treated with Calyculin A (50 ng/mL/20 min) for … cymbalta researchWebPhospho-IRF-3 (Ser396) Antibody detects endogenous levels of IRF-3 only when phosphorylated at Ser396. This antibody does not cross-react with other family members at physiological conditions. Species Reactivity: Human. Species predicted to react based on … Highly specific and rigorously validated in-house, Phospho-IRF-3 (Ser396) (4D4G) … billy jack haynes wrestlingWeb功能: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. billy jack haynes boys on the tracks