Carboxymethylenebutenolidase
WebApr 16, 2010 · Here, the identified protein, human carboxymethylenebutenolidase homolog (carboxymethylenebutenolidase-like protein (CMBL), GenBank TM accession … WebOlmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor blocker (ARB). We recently identified carboxymethylenebutenolidase homolog (CMBL) as the …
Carboxymethylenebutenolidase
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WebDec 1, 2001 · Function. Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor … WebNational Center for Biotechnology Information
WebDec 4, 2024 · CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20247059]). [supplied by OMIM, Apr 2010] WebBased on sequences of the N terminus and tryptic peptides of this enzyme, degenerate PCR primers were now designed and used for cloning of the respective gene from genomic DNA of strain 1CP. A 9.5-kb fragment containing nine open reading frames was …
In enzymology, a carboxymethylenebutenolidase (EC 3.1.1.45, also known as CMBL and dienelactone hydrolase) is an enzyme that catalyzes the chemical reaction 4-carboxymethylenebut-2-en-4-olide + H2O 4-oxohex-2-enedioate Thus, the two substrates of this enzyme are 4-carboxymethylenebut-2-en-4-olide and H2O, whereas its product is 4-oxohex-2-enedioate. WebMar 1, 2005 · Carboxymethylenebutenolidase is specific for dienelactone and has no activity toward enol-lactones. Catalytic activity 2- (5-oxo-2,5-dihydrofuran-2 …
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WebParaoxonase 1 (PON1), a component of high-density lipoprotein (HDL), is a calcium-dependent multifunctional enzyme that connects metabolisms of lipoproteins and homocysteine (Hcy). Both PON1 and Hcy have been implicated in human diseases, including atherosclerosis and neurodegeneration. echo boards verificationWebThere are now four groups of enzymes which contain catalytic triads and which are related by convergent evolution towards a stable, useful active site: the eukaryotic serine proteases, the cysteine proteases, subtilisins and the alpha/beta hydrolase fold enzymes. Publication types Research Support, Non-U.S. Gov't compounding interest investment advisorWebBenz (a)anthracene (BaA) is a polycyclic aromatic hydrocarbons (PAHs), that belongs to a group of carcinogenic and mutagenic persistent organic pollutants found in a variety of ecological habitats. In this study, the efficient biodegradation of BaA by a green alga Chlamydomonas reinhardtii (C. reinhardtii) CC-503 was investigated. compounding investment anual inputequationhttp://amigo.geneontology.org/amigo/term/GO:0008806 compounding is also calledWebcarboxymethylenebutenolidase activity Ontology molecular_function Synonyms 4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity, carboxymethylene … echo boilerWebTraductions en contexte de "En lever" en néerlandais-français avec Reverso Context : en de lever, lever en nieren, lever- en galaandoeningen echo bonitaWebcarboxymethylenebutenolidase Enzyme Commission Synonyms: maleylacetate enol-lactonase, dienelactone hydrolase, carboxymethylene butenolide hydrolase Standard Gibbs Free Energy (ΔrG'°): 16.73877 kcal/mol[Latendresse13] Citations: [Schmidt80] Gene-Reaction Schematic Expand/Contract the Schematic connections: Unification Links: compounding interest continuously formula